A complete list of publications can be found at: http://www.ncbi.nlm.nih.gov/pubmed/?term=bergmeier+w


Ueda Y, Higasa K, Kamioka Y, Kondo N, Horitani S, Ikeda Y, Bergmeier W, Fukui Y, Kinashi T. Rap1 organizes lymphocyte front-back polarity via RhoA signaling and talin1. iScience. 2023 Jul 11;26(8):107292. doi: 10.1016/j.isci.2023.107292. PMID: 37520697; PMCID: PMC10374465.

Kamioka Y, Ueda Y, Kondo N, Tokuhiro K, Ikeda Y, Bergmeier W, Kinashi T. Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow. Cell Rep. 2023 Jun 1;42(6):112580. doi: 10.1016/j.celrep.2023.112580. Epub ahead of print. PMID: 37267105.

Rudran T, Antoniak S, Flick MJ, Ginsberg MH, Wolberg AS, Bergmeier W, Lee RH. Protease-activated receptors and glycoprotein VI cooperatively drive the platelet component in thromboelastography. J Thromb Haemost. 2023 Aug;21(8):2236-2247. doi: 10.1016/j.jtha.2023.04.008. Epub 2023 Apr 15. PMID: 37068592.

Paul DS, Blatt TN, Schug WJ, Clark EG, Kawano T, Mackman N, Murcia S, Poe KO, Mwiza JMN, Harden TK, Bergmeier W, Nicholas RA. Loss of P2Y1 receptor desensitization does not impact hemostasis or thrombosis despite increased platelet reactivity in vitro. J Thromb Haemost. 2023 Jul;21(7):1891-1902. doi: 10.1016/j.jtha.2023.03.013. Epub 2023 Mar 21. PMID: 36958516.

Kawano T, Hisada Y, Grover SP, Schug WJ, Paul DS, Bergmeier W, Mackman N. Decreased Platelet Reactivity and Function in a Mouse Model of Human Pancreatic Cancer. Thromb Haemost. 2023 Jan 30. doi: 10.1055/s-0043-1761419. Epub ahead of print. PMID: 36716775.


Lee RH, Rocco DJ, Nieswandt B, Bergmeier W. The CalDAG-GEFI/Rap1/αIIbβ3 axis minimally contributes to accelerated platelet clearance in mice with constitutive store-operated calcium entry. Platelets. 2023 Dec;34(1):2157383. doi: 10.1080/09537104.2022.2157383. PMID: 36683325.

Spindler M, Bergmeier W, Stradal TEB, Zhang J, Siminovitch KA, Nicolai L, Reinhold A, Bender M. Novel insights into mouse models of ectopic proplatelet release. Blood Adv. 2022 Dec 27;6(24):6135-6139. doi: 10.1182/bloodadvances.2022007824. PMID: 36251748; PMCID: PMC9768245.

Johansen KH, Golec DP, Huang B, Park C, Thomsen JH, Preite S, Cannons JL, Garçon F, Schrom EC, Courrèges CJF, Veres TZ, Harrison J, Nus M, Phelan JD, Bergmeier W, Kehrl JH, Okkenhaug K, Schwartzberg PL. A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1-mediated adhesion in T cells. Sci Signal. 2022 Jul 19;15(743):eabl9169. doi: 10.1126/scisignal.abl9169. Epub 2022 Jul 19. PMID: 35857633.

Mwiza JMN, Lee RH, Paul DS, Holle LA, Cooley BC, Nieswandt B, Schug WJ, Kawano T, Mackman N, Wolberg AS, Bergmeier W. Both G protein-coupled and immunoreceptor tyrosine-based activation motif receptors mediate venous thrombosis in mice. Blood. 2022 May 26;139(21):3194-3203. doi: 10.1182/blood.2022015787. PMID: 35358299.

Chen W, Wilson MS, Wang Y, Bergmeier W, Lanza F, Li R. Fast clearance of platelets in a commonly used mouse model for GPIbα is impeded by an anti-GPIbβ antibody derivative. J Thromb Haemost. 2022 Jun;20(6):1451-1463. doi: 10.1111/jth.15702. Epub 2022 Mar 29. PMID: 35305057; PMCID: PMC9133214.

Lee RH, Ghalloussi D, Harousseau GL, Kenny JP, Kramer PA, Proamer F, Nieswandt B, Flick MJ, Gachet C, Casari C, Eckly A, Bergmeier W. Rasa3 deficiency minimally affects thrombopoiesis but promotes severe thrombocytopenia due to integrin-dependent platelet clearance. JCI Insight. 2022 Apr 22;7(8):e155676. doi: 10.1172/jci.insight.155676. PMID: 35290242; PMCID: PMC9089782.

Shao B, Hoover C, Shi H, Kondo Y, Lee RH, Chen J, Shan X, Song J, McDaniel JM, Zhou M, McGee S, Vanhoorelbeke K, Bergmeier W, López JA, George JN, Xia L. Deletion of platelet CLEC-2 decreases GPIbα-mediated integrin αIIbβ3 activation and decreases thrombosis in TTP. Blood. 2022 Apr 21;139(16):2523-2533. doi: 10.1182/blood.2021012896. PMID: 35157766; PMCID: PMC9029097.

Hur WS, Paul DS, Bouck EG, Negrón OA, Mwiza JM, Poole LG, Cline-Fedewa HM, Clark EG, Juang LJ, Leung J, Kastrup CJ, Ugarova TP, Wolberg AS, Luyendyk JP, Bergmeier W, Flick MJ. Hypofibrinogenemia with preserved hemostasis and protection from thrombosis in mice with an Fga truncation mutation. Blood. 2022 Mar 3;139(9):1374-1388. doi: 10.1182/blood.2021012537. PMID: 34905618; PMCID: PMC8900273.

Lee RH, Kawano T, Grover SP, Bharathi V, Martinez D, Cowley DO, Mackman N, Bergmeier W, Antoniak S. Genetic deletion of platelet PAR4 results in reduced thrombosis and impaired hemostatic plug stability. J Thromb Haemost. 2022 Feb;20(2):422-433. doi: 10.1111/jth.15569. Epub 2021 Nov 10.


Hoover CM, Kondo Y, Shao B, McDaniel M, Lee R, McGee S, Whiteheart SW, Bergmeier W, McEver RP, Xia L. Heightened activation of embryonic megakaryocytes causes aneurysms in the developing brain of mice lacking podoplanin. Blood. 2021 Feb 22:blood.2020010310. doi: 10.1182/blood.2020010310.

Ross JE, Zhang BM, Lee K, Mohan S, Branchford BR, Bray P, Dugan SN, Freson K, Heller PG, Kahr WHA, Lambert MP, Luchtman-Jones L, Luo M, Perez Botero J, Rondina MT, Ryan G, Westbury S, Bergmeier W, Di Paola J. Specifications of the variant curation guidelines for ITGA2B/ITGB3: ClinGen Platelet Disorder Variant Curation Panel. Blood Adv. 2021 Jan 26;5(2):414-431. doi: 10.1182/bloodadvances.2020003712.PMID: 33496739 

Wang Y, Chen W, Zhang W, Lee-Sundlov MM, Casari C, Berndt MC, Lanza F, Bergmeier W, Hoffmeister KM, Zhang XF, Li R. Desialylation of O-glycans on glycoprotein Ibα drives receptor signaling and platelet clearance. Haematologica. 2021 Jan 1;106(1):220-229. doi: 10.3324/haematol.2019.240440.


Lee RH, Kasthuri RS, Bergmeier W. Platelet transfusion for patients with platelet dysfunction: effectiveness, mechanisms, and unanswered questions. Curr Opin Hematol. 2020 Nov;27(6):378-385. doi:10.1097/MOH.0000000000000608. PMID: 32868672

Eckly A, Scandola C, Oprescu A, Michel D, Rinckel JY, Proamer F, Hoffmann D, Receveur N, Léon C, Bear JE, Ghalloussi D, Harousseau G, Bergmeier W, Lanza F, Gaits-Iacovoni F, de la Salle H, Gachet C. Megakaryocytes use in vivo podosome-like structures working collectively to penetrate the endothelial barrier of bone marrow sinusoids. J Thromb Haemost. 2020 Jul 23. doi: 10.1111/jth.15024. PMID: 32702204

Ariens R, Becattini C, Bender M, Bergmeier W, Castoldi E, Devreese K, Ellis M, Gailani D, Ignjatovic V, James PD, Kerrigan S, Lambert M, Lee LH, Levi M, Maugeri N, Meijers J, Melero-Martin J, Michelson AD, Mingozzi F, Neeves K, Ni H, Olsson AK, Prohászka Z, Ranson M, Riva N, Senis Y, van Ommen CH, Vaughan DE, Weisel J. Illustrated State-of-the-Art Capsules of the ISTH 2020 Congress. Res Pract Thromb Haemost. 2020 Jul 12;4(5):680-713. doi: 10.1002/rth2.12368. eCollection 2020 Jul.PMID: 32685876 

Paul DS, Bergmeier W.  Novel Mouse Model for Studying Hemostatic Function of Human Platelets. Arterioscler Thromb Vasc Biol. 2020 Jun 4:ATVBAHA120314304. doi: 10.1161/ATVBAHA.120.314304. PMID: 32493172

Lagarrigue F, Paul DS, Gingras AR, Valadez AJ, Sun H, Lin J, Cuevas MN, Ablack JNG, Lopez Ramirez MA, Bergmeier W, Ginsberg MH. Talin1 is the Principal Platelet Rap1 Effector of Integrin Activation. Blood. 2020 Jun 9:blood.2020005348. doi: 10.1182/blood.2020005348. PMID: 32518959

Klein MK, Kassam HA, Lee RH, Bergmeier W, Peters EB, Gillis DC, Dandurand BR, Rouan JR, Karver MR, Struble MD, Clemons TD, Palmer LC, Gavitt B, Pritts TA, Tsihlis ND, Stupp SI, Kibbe MR.  Development of Optimized Tissue-Factor-Targeted Peptide Amphiphile Nanofibers to Slow Noncompressible Torso Hemorrhage.  ACS Nano. 2020 Jun 3. doi: 10.1021/acsnano.9b09243. Online ahead of print.PMID: 32469498

d’Alessandro E, Becker C, Bergmeier W, et al. Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis. Thromb Haemost. 2020;120(4):538‐564. doi:10.1055/s-0040-1708035

Mackman N, Bergmeier W, Stouffer GA, Weitz JI.  Therapeutic Strategies for Thrombosis: New Targets and Approaches.  Nat Rev Drug Discov. 2020 May;19(5):333-352. doi: 10.1038/s41573-020-0061-0. Epub 2020 Mar 4.PMID: 32132678

Karhausen J, Choi HW, Maddipati KR, Mathew JP, Ma Q, Boulaftali Y, Lee RH, Bergmeier W, Abraham SN. Platelets trigger perivascular mast cell degranulation to cause inflammatory responses and tissue injury.  Sci Adv. 2020 Mar 18;6(12):eaay6314. doi: 10.1126/sciadv.aay6314. eCollection 2020 Mar.

Botero JP, Lee K, Branchford BR, Bray PF, Freson K, Lambert MP, Luo M, Mohan S, Ross JE, Bergmeier W, Di Paola J; ClinGen Platelet Disorder Variant Curation Expert Panel. Glanzmann thrombasthenia: genetic basis and clinical correlates.  Haematologica. 2020 Mar 5. pii: haematol.2018.214239. doi: 10.3324/haematol.2018.214239. [Epub ahead of print]

Wang Y, Chen W, Zhang W, Lee-Sundlov MM, Casari C, Berndt MC, Lanza F, Bergmeier W, Hoffmeister KM, Zhang XF, Li R. Desialylation of O-glycans on glycoprotein Ibα drives receptor signaling and platelet clearance.  Haematologica. 2020 Jan 23. pii: haematol.2019.240440. doi: 10.3324/haematol.2019.240440.


Lee RH, Piatt R, Dhenge A, Lozano ML, Palma-Barqueros V, Rivera J, Bergmeier W. Impaired hemostatic activity of healthy transfused platelets in inherited and acquired platelet disorders: Mechanisms and implications.   Sci Transl Med. 2019 Dec 11;11(522). pii: eaay0203. doi: 10.1126/scitranslmed.aay0203.

Holly SP, Gera N, Wang P, Wilson A, Guan Z, Lin L, Cooley B, Alfar HR, Patil RG, Piatt R, Leisner TM, Bergmeier W, Majumder R, Parise LV. Ether lipid metabolism by AADACL1 regulates platelet function and thrombosis.  Blood Adv. 2019 Nov 26;3(22):3818-3828. doi: 10.1182/bloodadvances.2018030767.

Sarker M, Goliaei A, Golesi F, Poggi M, Cook AA, Khan MAI, Temple BR, Stefanini L, Canault M, Bergmeier W, Campbell SL. Subcellular localization of Rap1 GTPase activator CalDAG-GEFI is orchestrated by interaction of its atypical C1 domain with membrane phosphoinositides.  J Thromb Haemost. 2020 Mar;18(3):693-705. doi: 10.1111/jth.14687. Epub 2019 Dec 30.

Ghalloussi D, Dhenge A, Bergmeier W. New insights into cytoskeletal remodeling during platelet production.  J Thromb Haemost. 2019 Sep;17(9):1430-1439. doi: 10.1111/jth.14544. Epub 2019 Jul 16. Review.

Misumi I, Cook KD, Mitchell JE, Lund MM, Vick SC, Lee RH, Uchimura T, Bergmeier W, Mieczkowski P, Pardo-Manuel de Villena F, Ting JPY, Whitmire JK. Identification of a Locus in Mice that Regulates the Collateral Damage and Lethality of Virus Infection. Cell Rep. 2019 Apr 30;27(5):1387-1396.e5. doi: 10.1016/j.celrep.2019.04.004.

Faes C, Ilich A, Sotiaux A, Sparkenbaugh EM, Henderson MW, Buczek L, Beckman JD, Ellsworth P, Noubouossie DF, Bhoopat L, Piegore M, Renoux C, Bergmeier W, Park Y, Ataga KI, Cooley B, Wolberg AS, Key NS, Pawlinski R. Red blood cells modulate structure and dynamics of venous clot formation in sickle cell disease.  Blood. 2019 Jun 6;133(23):2529-2541. doi: 10.1182/blood.2019000424. Epub 2019 Apr 5.

Stefanini L, Bergmeier W. Small GTPases in megakaryocyte and platelet biology.  Platelets. 2019;30(1):7-8. doi: 10.1080/09537104.2018.1560938. Epub 2019 Jan 20.


Wu B, Zhang S, Guo Z, Wang G, Zhang G, Xie L, Lou J, Chen X, Wu D, Bergmeier W, Zheng J, Wan YY. RAS P21 Protein Activator 3 (RASA3) Specifically Promotes Pathogenic T Helper 17 Cell Generation by Repressing T-Helper-2-Cell-Biased Programs.  Immunity. 2018 Nov 20;49(5):886-898.e5. doi: 10.1016/j.immuni.2018.09.004. Epub 2018 Nov 13.

Roweth HG, Cook AA, Moroi M, Bonna AM, Jung SM, Bergmeier W, Sage SO, Jarvis GE. Two novel, putative mechanisms of action for citalopram-induced platelet inhibition.  Sci Rep. 2018 Nov 12;8(1):16677. doi: 10.1038/s41598-018-34389-5.

Gamage TH, Gunnes G, Lee RH, Louch WE, Holmgren A, Bruton JD, Lengle E, Kolstad TRS, Revold T, Amundsen SS, Dalen KT, Holme PA, Tjønnfjord GE, Christensen G, Westerblad H, Klungland A, Bergmeier W, Misceo D, Frengen E. STIM1 R304W causes muscle degeneration and impaired platelet activation in mice.   2018 Dec;76:87-100. doi: 10.1016/j.ceca.2018.10.001. Epub 2018 Oct 5.

Lagarrigue F, Gingras AR, Paul DS, Valadez AJ, Cuevas MN, Sun H, Lopez-Ramirez MA, Goult BT, Shattil SJ, Bergmeier W, Ginsberg MH. Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation.  Blood Adv. 2018 Sep 25;2(18):2358-2368. doi: 10.1182/bloodadvances.2018020487.

Stefanini L, Lee RH, Paul DS, O’Shaughnessy EC, Ghalloussi D, Jones CI, Boulaftali Y, Poe KO, Piatt R, Kechele DO, Caron KM, Hahn KM, Gibbins JM, Bergmeier W. Functional redundancy between RAP1 isoforms in murine platelet production and function.  Blood. 2018 Aug 21. pii: blood-2018-03-838714. doi: 10.1182/blood-2018-03-838714. [Epub ahead of print]

Bergmeier W, Antoniak S, Conway EM, Denis CV, George LA, Isermann B, Key NS, Krishnaswamy S, Lam WA, Lillicrap D, Liu J, Looney MR, López JA, Maas C, Peyvandi F, Ruf W, Sood AK, Versteeg HH, Wolberg AS, Wong PC, Wood JP, Weiler H. Advances in Clinical and Basic Science of Coagulation: Illustrated abstracts of the 9th Chapel Hill Symposium on Hemostasis.  Res Pract Thromb Haemost. 2018 Apr 12;2(3):407-428. doi: 10.1002/rth2.12095. eCollection 2018 Jul. Review.

Desai A, Bergmeier W, Canault M, Alessi MC, Paul DS, Nurden P, Pillois X, Jy W, Ahn YS, Nurden AT. Phenotype analysis and clinical management in a large family with a novel truncating mutation in RASGRP2, the CalDAG-GEFI encoding gene.  Res Pract Thromb Haemost. 2017 Jun 20;1(1):128-133. doi: 10.1002/rth2.12019. eCollection 2017 Jul.

Akbar H, Duan X, Piatt R, Saleem S, Davis AK, Tandon NN, Bergmeier W, Zheng Y. Small molecule targeting the Rac1-NOX2 interaction prevents collagen-related peptide and thrombin-induced reactive oxygen species generation and platelet activation.  J Thromb Haemost. 2018 Oct;16(10):2083-2096. doi: 10.1111/jth.14240. Epub 2018 Aug 13.

Casari C, Paul DS, Susen S, Lavenu-Bombled C, Harroche A, Piatt R, Poe KO, Lee RH, Bryckaert M, Christophe OD, Lenting PJ, Denis CV, Bergmeier W. Protein kinase C signaling dysfunction in von Willebrand disease (p.V1316M) type 2B platelets.  Blood Adv. 2018 Jun 26;2(12):1417-1428. doi: 10.1182/bloodadvances.2017014290.

Stefanini L, Bergmeier W. RAP GTPases and platelet integrin signaling.  Platelets. 2018 Jun 4:1-7. doi: 10.1080/09537104.2018.1476681. [Epub ahead of print]

Cook AA, Deng W, Ren J, Li R, Sondek J, Bergmeier W. Calcium-induced structural rearrangements release autoinhibition in the Rap-GEF CalDAG-GEFI.  J Biol Chem. 2018 Jun 1;293(22):8521-8529. doi: 10.1074/jbc.RA118.002712. Epub 2018 Apr 5.

Grover SP, Bergmeier W, Mackman N. Platelet Signaling Pathways and New Inhibitors.  Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):e28-e35. doi: 10.1161/ATVBAHA.118.310224. Review.

Bergmeier W, Stefanini L. Platelets at the Vascular Interface.  Res Pract Thromb Haemost. 2018 Jan;2(1):27-33. doi: 10.1002/rth2.12061. Epub 2017 Dec 22.

Plautz WE, Sekhar Pilli VS, Cooley BC, Chattopadhyay R, Westmark PR, Getz T, Paul D, Bergmeier W, Sheehan JP, Majumder R. Anticoagulant Protein S Targets the Factor IXa Heparin-Binding Exosite to Prevent Thrombosis.  Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):816-828. doi: 10.1161/ATVBAHA.117.310588. Epub 2018 Feb 1.

Stefanini L, Bergmeier W. Negative regulators of platelet activation and adhesion.  J Thromb Haemost. 2018 Feb 16(2):220-230. doi: 10.1111/jth.13910.


Paul DS, Casari C, Wu C, Piatt R, Pasala, Campbell RA, Poe KO, Ghalloussi D, Lee RH, Rotty JD, Cooley BC, Machlus KR, Italiano JE, Weyrich AS, Bear JE, Bergmeier W. Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice.  

Sevivas T, Bastida JM, Paul DS, Caparros E, Palma-Barqueros V, Coucelo M, Marques D, Ferrer-Marín F, González-Porras JR, Vicente V, Hernández-Rivas JM, Watson SP, Lozano ML, Bergmeier W, Rivera J. Identification of two novel mutations in RASGRP2 affecting platelet CalDAG-GEFI expression and function in patients with bleeding diathesis.  Platelets. 2017 Aug 1:1-4. doi: 10.1080/09537104.2017.1336214. [Epub ahead of print]

Bermejo E, Alberto MF, Paul DS, Cook AA, Nurden P, Sanchez Luceros A, Nurden AT, Bergmeier W. Marked bleeding diathesis in patients with platelet dysfunction due to a novel mutation in RASGRP2, encoding CalDAG-GEFI (p.Gly305Asp).  Platelets. 2017 Jul 20:1-3. doi: 10.1080/09537104.2017.1332759. [Epub ahead of print]

Lee RH, Bergmeier W. Sugar makes neutrophils RAGE: linking diabetes-associated hyperglycemia to thrombocytosis and platelet reactivity.  J Clin Invest. 2017 Jun 1;127(6):2040-2043. doi: 10.1172/JCI94494. Epub 2017 May 15.

Lee RH, Piatt R, Conley PB, Bergmeier W. Effects of ibrutinib treatment on murine platelet function during inflammation and in primary hemostasis.  2017 Mar;102(3):e89-e92. doi: 10.3324/haematol.2016.155978. Epub 2016 Dec 15.

Battram AM, Durrant TN, Agbani EO, Heesom KJ, Paul DS, Piatt R, Poole AW, Cullen PJ, Bergmeier W, Moore SF, Hers I.  The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbβ3 Outside-in Signaling.  J Biol Chem. 2017 Feb 3;292(5):1691-1704. doi: 10.1074/jbc.M116.746867. Epub 2016 Nov 30.


Deng W, Xu Y, Chen W, Paul DS, Syed AK, Dragovich MA, Liang X, Zakas P, Berndt MC, Di Paola J, Ware J, Lanza F, Doering CB, Bergmeier W, Zhang XF, Li R. Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor.  Nat Commun. 2016 Sep 27;7:12863. doi: 10.1038/ncomms12863.

Piatt R, Paul DS, Lee RH, McKenzie SE, Parise LV, Cowley DO, Cooley BC, Bergmeier W. Mice Expressing Low Levels of CalDAG-GEFI Exhibit Markedly Impaired Platelet Activation With Minor Impact on Hemostasis.  ATVB. 2016 July 14. pii:ATVBAHA.116.307874.

Lozano ML, Cook A, Bastida JM, Paul DS, Iruin G, Cid AR, Adan-Pedroso R, González-Porras JR, Hernández-Rivas JM, Fletcher SJ, Johnson B, Morgan N, Ferrer-Marin F, Vicente V, Sondek J, Watson SP, Bergmeier W, Rivera J. Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction.  Blood. 2016 May 27. pii: blood-2015-11-683102.

Casari C, Bergmeier W. Acquired platelet disorders.  Thromb Res. 2016 May;141 Suppl 2:S73-5. doi: 10.1016/S0049-3848(16)30371-1.

Hisada Y, Geddings JE, Boulaftali Y, Getz TM, Whelihan M, Fuentes R, Dee R, Cooley BC, Key NS, Wolberg AS, Bergmeier W, Mackman N. OC-04 – Tissue factor positive microvesicles activate platelets in vitro and in vivo and enhance thrombosis in mice.  Thromb Res. 2016 Apr;140 Suppl 1:S169-70. doi: 10.1016/S0049-3848(16)30121-9. Epub 2016 Apr 8.

Ren J, Cook AA, Bergmeier W, Sondek J.  Biochem Biophys Res Commun. A negative-feedback loop regulating ERK1/2 activation and mediated by RasGPR2 phosphorylation. 2016 May 20;474(1):193-8. doi: 10.1016/j.bbrc.2016.04.100. Epub 2016 Apr 21.

Boulaftali Y, Owens AP 3rd, Beale A, Piatt R, Casari C, Lee RH, Conley PB, Paul DS, Mackman N,Bergmeier W.   CalDAG-GEFI Deficiency Reduces Atherosclerotic Lesion Development in Mice.  Arterioscler Thromb Vasc Biol. 2016 May;36(5):792-9. doi: 10.1161/ATVBAHA.115.306347. Epub 2016 Mar 17.

Freeman SA, Goyette J, Furuya W, Woods EC, Bertozzi CR, Bergmeier W, Hinz B, van der Merwe PA, Das R, Grinstein S.  Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis. Cell. 2016 Jan 14;164(1-2):128-40.

Lee RH, Bergmeier W. Platelet immunoreceptor tyrosine-based activation motif (ITAM) and hemITAM signaling and vascular integrity in inflammation and development. J Thromb Haemost. 2016 Jan 9.

Machlus KR, Wu SK, Stumpo DJ, Soussou TS, Paul DS, Campbell RA, Kalwa H, Michel T, Bergmeier W, Weyrich AS, Blackshear PJ, Hartwig JH, Italiano JE Jr.
Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation. Blood. 2016 Jan 7.

Geddings JE, Hisada Y, Boulaftali Y, Getz TM, Whelihan M, Fuentes R, Dee R, Cooley BC, Key NS, Wolberg AS, Bergmeier W, Mackman N. Tissue factor-positive tumor microvesicles activate platelets and enhance thrombosis in mice.  J Thromb Haemost. 2016 Jan;14(1):153-66.


Stefanini L, Bergmeier W. RAP1-GTPase signaling and platelet function. J Mol Med (Berl). 2016 Jan;94(1):13-9.

Bergmeier W, Stefanini L. Platelet signaling–blood’s great balancing act. Oncotarget. 2015 Aug 21;6(24):19922-3

Su W, Wynne J, Pinheiro EM, Strazza M, Mor A, Montenont E, Berger J, Paul DS, Bergmeier W, Gertler FB, Philips MR. Rap1 and its effector RIAM are required for lymphocyte trafficking. Blood. 2015 Dec 17;126(25):2695-703.

Owens AP 3rd, Edwards TL, Antoniak S, Geddings JE, Jahangir E, Wei WQ, Denny JC, Boulaftali Y, Bergmeier W, Daugherty A, Sampson UK, Mackman N. Platelet Inhibitors Reduce Rupture in a Mouse Model of Established Abdominal Aortic Aneurysm.  Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):2032-41.

Stefanini L, Paul DS, Robledo RF, Chan ER, Getz TM, Campbell RA, Kechele DO, Casari C, Piatt R, Caron KM, Mackman N, Weyrich AS, Parrott MC, Boulaftali Y, Adams MD, Peters LL, Bergmeier W. RASA3 is a critical inhibitor of RAP1-dependent platelet activation. J Clin Invest. 2015 Apr;125(4):1419-32.

Getz TM, Piatt R, Petrich BG, Monroe D, Mackman N, Bergmeier W. Platelet Inhibitors Reduce Rupture in a Mouse Model of Established Abdominal Aortic Aneurysm.  J Thromb Haemost. 2015 Mar;13(3):417-25.


Amirkhosravi A, Boulaftali Y, Robles-Carrillo L, Meyer T, McKenzie SE, Francis JL, Bergmeier W. CalDAG-GEFI deficiency protects mice from FcγRIIa-mediated thrombotic thrombocytopenia induced by CD40L and β2GPI immune complexes.  J Thromb Haemost. 2014 Dec;12(12):2113-9.

Gomez JC, Yamada M, Martin JR, Dang H, Brickey WJ, Bergmeier W, Dinauer MC, Doerschuk CM. Mechanisms of interferon-γ production by neutrophils and its function during Streptococcus pneumoniae pneumonia.  Am J Respir Cell Mol Biol. 2015 Mar;52(3):349-64.

Walton BL, Getz TM, Bergmeier W, Lin FC, Uitte de Willige S, Wolberg AS. The fibrinogen γA/γ’ isoform does not promote acute arterial thrombosis in mice.  J Thromb Haemost. 2014 May;12(5):680-9.

Bergmeier W, Boulaftali Y. Adoptive transfer method to study platelet function in mouse models of disease. Thromb Res. 2014 May;133 Suppl 1:S3-5.

Boulaftali Y, Hess PR, Kahn ML, Bergmeier W. Platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling and vascular integrity. Circ Res. 2014 Mar 28;114(7):1174-84.

Stefanini L, Ye F, Snider AK, Sarabakhsh K, Piatt R, Paul DS, Bergmeier W, Petrich BG. A talin mutant that impairs talin-integrin binding in platelets decelerates αIIbβ3 activation without pathological bleeding.  Blood. 2014 Apr 24;123(17):2722-31.


Holly SP, Chang JW, Li W, Niessen S, Phillips RM, Piatt R, Black JL, Smith MC, Boulaftali Y, Weyrich AS, Bergmeier W,  Cravatt BF and Parise LV. Chemoproteomic discovery of AADACL1 as a regulator of human platelet activation. Chem Biol. 2013 Sep 19;20(9):1125-34. doi: 10.1016/j.chembiol.2013.07.011. Epub 2013 Aug 29.

Bergmeier W, Stefanini L. Platelet ITAM signaling.  Current Opinion Hematology, 2013 Sep;20(5):445-50.

Bergmeier W, Weidinger C, Zee I, Feske S. Emerging roles of store-operated Ca²⁺ entry through STIM and ORAI proteins in immunity, hemostasis and cancer. Channels (Austin). 2013 Mar 19;7(4).

Boulaftali Y, Hess PR, Getz TM, Cholka A, Stolla M, Mackman N, Owens III AP, Ware J, Kahn ML, Bergmeier W.  Platelet ITAM signaling is critical for vascular integrity in inflammation.  J Clin Invest.  2013 Feb 1;123(2):908-16.  Editorial in the Hematologist

       Faculty of 1000 rating: *****


Xiang B, Zhang G, Stefanini L, Bergmeier W, Gartner TK, Whiteheart SW, Li Z. The Src family kinases and protein kinase C synergize to mediate Gq-dependent platelet activation.  J Biol Chem. 2012 Nov 30;287(49):41277-87.

Edelstein LC, Luna EJ, Gibson IB, Bray M, Jin Y, Kondkar A, Nagalla S, Hadjout-Rabi N, Smith TC, Covarrubias D, Jones SN, Ahmad F, Stolla M, Kong X, Fang Z, Bergmeier W, Shaw C, Leal SM, Bray PF. Human genome-wide association and mouse knockout approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stress. Circulation, 2012 Jun 5;125(22):2762-71.

Jansen AJ, Josefsson EC, Rumjantseva V, Liu QP, Falet H, Bergmeier W, Cifuni SM, Sackstein R, von Andrian UH, Wagner DD, Hartwig JH, Hoffmeister KM. Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice.  Blood 2012 Feb 2;119(5) 1263-73.

Stefanini L, Boulaftali Y, Ouellette TD, Holinstat M, Désiré L, Leblond B, Andre P, Conley PB, Bergmeier W. Rap1-Rac1 circuits potentiate platelet activation.  Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):434-41.

Bergmeier W and Hynes RO. Extracellular matrix proteins in hemostasis and thrombosis. Cold Spring Harb Perspect Biol. 2012 Feb 1;4(2).


Ahmad F, Boulaftali Y, Greene TK, Ouellette TD, Poncz M, Feske S, Bergmeier W. Relative contributions of stromal interaction molecule 1 and CalDAG-GEFI to calcium-dependent platelet activation and thrombosis.  J Thromb Haemost. 2011 Oct;9(10):2077-86

Stadtmann A, Brinkhaus L, Mueller H, Rossaint J, Bolomini-Vittori M, Bergmeier W, Van Aken H, Wagner DD, Laudanna C, Ley K, Zarbock A. Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rolling.  Eur J Immunol. 2011 Jul;41(7):2074-85.

Reilly MP, Sinha U, André P, Taylor SM, Pak Y, Deguzman FR, Nanda N, Pandey A, Stolla M, Bergmeier W, McKenzie SE. PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model.  Blood. 2011 Feb 17;117(7):2241-6. doi: 10.1182/blood-2010-03-274969. Epub 2010 Nov 18.

Cosemans JM, Schols SE, Stefanini L, de Witt S, Feijge MA, Hamulyák K, Deckmyn H, Bergmeier W, Heemskerk JW. Key role of glycoprotein Ib/V/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flow.  Blood. 2011 Jan 13;117(2):651-60. doi: 10.1182/blood-2010-01-262683. Epub 2010 Oct 29.

Faculty of 1000 rating: *

Hong W, Kondkar AA, Nagalla S, Bergmeier W, Jin Y, Herman JH, Bray PF. Transfection of human platelets with short interfering RNA.  Clin Transl Sci. 2011 Jun;4(3):180-2.

Stolla M, Stefanini L, André P, Ouellette TD, Reilly MP, McKenzie SE, Bergmeier W. CalDAG-GEFI deficiency protects mice in a novel model of Fcγ RIIA-mediated thrombosis and thrombocytopenia.  Blood. 2011 Jul 28;118(4):1113-20.

Stolla M, Stefanini L, Roden RC, Hirsch J, Greene T, Ouellette TD, Maloney SF, Diamond SL, Poncz M, Bergmeier W.  The kinetics of αIIbβ3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy.  Blood 2011, Jan 20; 117 (3):1005-13


Stefanini L, Bergmeier W. CalDAG-GEFI and platelet activation. Platelets 2010; 21(4): 239-43

Canault M, Duerschmied D, Brill A, Stefanini L, Schatzberg D, Cifuni SM, Bergmeier W, Wagner DD. p38 mitogen-activated protein kinase activation during platelet storage: consequences for platelet recovery and hemostatic function in vivo.  Blood 2010, Mar 4;115 (9):1835-42


Bergmeier W, Stefanini L. Novel molecules in calcium signaling in platelets. J Thromb Haemost. 2009 Jul;7 Suppl 1:187-90.

Stefanini L, Roden RC, Bergmeier W. CalDAG-GEFI is at the nexus of calcium-dependent platelet activation. Blood 2009, Sep 17;114(12):2506-14.

Brill A, Chauhan AK, Canault M, Walsh MT, Bergmeier W, Wagner DD. Oxidative stress activates ADAM17/TACE and induces its target receptor shedding in platelets in a p38-dependent fashion. Cardiovasc Res. 2009 Oct 1;84(1):137-44.

Bergmeier W, Oh-Hora M, McCarl CA, Roden RC, Bray PF, Feske S. R93W mutation in Orai1 causes impaired calcium influx in platelets. Blood 2009 Jan 15;113(3):675-8.


Cifuni SM, Wagner DD, Bergmeier W. CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets. Blood 2008 Sep 1; 112(5):1696-703.

Dole VS, Matuskova J, Vasile E, Yesilaltay A, Bergmeier W, Bernimoulin M, Wagner DD, Krieger M. Thrombocytopenia and platelet abnormalities in high-density lipoprotein receptor-deficient mice.  Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1111-6

Bergmeier W, Chauhan AK, Wagner DD. Glycoprotein Ibalpha and von Willebrand factor in primary platelet adhesion and thrombus formation: lessons from mutant mice. Thromb Haemost. 2008 Feb;99(2):264-70.


Dole VS, Bergmeier W, Patten IS, Hirahashi J, Mayadas TN, Wagner DD. PSGL-1 regulates platelet P-selectin-mediated endothelial activation and shedding of P-selectin from activated platelets. Thromb Haemost. 2007 Oct;98(4):806-12.

Bergmeier W, Goerge T, Wang HW, Crittenden JR, Baldwin ACW, Cifuni SM, Housman DE, Graybiel AM, Wagner DD. Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III.  J Clin Invest. 2007 Jun;117 (6):1699-707.

            Faculty of 1000 rating: **

Zhu L, Bergmeier W, Wu J, Jiang H, Stalker TJ, Cieslak M, Fan R, Boumsell L, Kumanogoh A, Kikutan H, Tamagnone L, Wagner DD, Milla ME, Brass LF. Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury. Proc Natl Acad Sci U S A 104(5):1621-1626, 2007.

            Faculty of 1000 rating: **

Babic AM, Josefsson EC, Bergmeier W, Wagner DD, Kaufman RM, Silberstein LE, Stossel TP, Hartwig JH, Hoffmeister KM. In vitro function and phagocytosis of galactosylated platelet concentrates after long-term refrigeration. Transfusion 47(3): 442-451, 2007.

Chauhan AK, Kisucka J, Lamb CB, Bergmeier W, Wagner DD. von Willebrand factor and factor VIII are independently required to form stable occlusive thrombi in injured veins. Blood. 2007 Mar 15;109(6):2424-9


Bergmeier W, Piffath CL, Goerge T, Cifuni SM, Ruggeri ZM, Ware J, Wagner DD. The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis. Proc Natl Acad Sci U S A 103(45):16900-16905, 2006.

            Faculty of 1000 rating: ****

Chauhan AK, Motto DG, Lamb CB, Bergmeier W, Dockal M, Plaimauer B, Scheiflinger F, Ginsburg D, Wagner DD. Systemic antithrombotic effects of ADAMTS13. J Exp Med 203 (3):767-776, 2006.

Bergmeier W and Wagner DD. Inflammation. In: Platelets, 2nd Edition, Michelson, A. (Ed.). San Diego: Elsevier/Academic Press, 2006.


Aktas B, Pozagajova M, Bergmeier W, Sunnarborg SW, Offermanns S, Lee DC, Wagner DD, Nieswandt B. Aspirin induces platelet receptor shedding via ADAM17 (TACE). J Biol Chem. 280(48):39716-22, 2005.

Dole VS, Bergmeier W, Mitchell HA, Eichenberger SC, Wagner DD. Activated platelets induce Weibel-Palade-body secretion and leukocyte rolling in vivo: role of P-selectin. Blood 106: 2334-2339, 2005.

            Faculty of 1000 rating: *

Cai S, Dole VS, Bergmeier W, Scafidi J, Feng H, Wagner DD, Davis AE 3rd.  A direct role for C1 inhibitor in regulation of leukocyte adhesion. J Immunol 174: 6462-6466, 2005. 

Morrell CN, Matsushita K, Chiles K, Scharpf RB, Yamakuchi M, Mason RJ, Bergmeier W, Mankowski JL, Baldwin WM 3rd, Faraday N, Lowenstein CJ.  Regulation of platelet granule exocytosis by S-nitrosylation.  Proc Natl Acad Sci U S A. 2005 Mar 8;102(10): 3782-7.


Schulze H, Korpal M, Bergmeier W, Italiano Jr, JE, Wahl SM, Shivdasani RA. Interactions between the megakaryocyte/platelet-specific beta1 tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet functions. Blood, 104(13):3949-57, 2004.

Crittenden JR*, Bergmeier W*, Zhang Y, Piffath CL, Liang Y, Wagner DD, Housman DE, Graybiel AM. CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation. Nat Med, 10(9):982-6, 2004.

            Faculty of 1000 rating: **

Bergmeier W, Piffath CL, Cheng G, Dole VS, Zhang Y, von Andrian UH, Wagner DD. Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates GPIbalpha shedding from platelets in vitro and in vivo. Circ Res, 95(7):677-83, 2004.

Bergmeier W*, Rabie T*, Strehl A, Piffath CL, Prostredna M, Wagner DD, Nieswandt B. GPVI down-regulation in murine platelets through metalloproteinase-dependent shedding. Thromb Haemost, 91(5):951-958, 2004.

Nieswandt B, Schulte V, and Bergmeier W. Flow-cytometric analysis of mouse platelet function. Methods Mol Biol, 272:255-68, 2004.


Cambien B, Bergmeier W, Saffaripour S, Wagner DD.  Antithrombotic activity of TNF-alpha.  J Clin Invest 112: 1589-1596, 2003.

Bergmeier W, Burger PC, Piffath CL, Hoffmeister KM, Hartwig JH, Nieswandt B, Wagner DD. Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro-aged or -injured mouse platelets.  Blood 102: 4229-4235, 2003.

Poujol C, Bergmeier W, Nurden P, Nieswandt B, Nurden A. Effect of infusing rat monoclonal antibodies to the murine GPIb-IX-V complex on platelet and megakaryocyte morphology in mice. Platelets. 14:35-45, 2003.

Nieswandt B, Bergmeier W, Schulte V, Takai T, Baumann U, Schmidt RE, Zirngibl H, Bloch W, Gessner JE. Targeting of platelet integrin alphaIIbbeta3 determines systemic reaction and bleeding in murine thrombocytopenia regulated by activating and inhibitory FcgammaR. Int Immunol. 15:341-349, 2003.

Kuijpers MJ, Schulte V, Bergmeier W, Lindhout T, Brakebusch C, Offermanns S, Fassler R, Heemskerk JW, Nieswandt B. Complementary roles of glycoprotein VI and alpha2beta1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo. Faseb J. 17:685-687, 2003.

Italiano JE, Jr., Bergmeier W, Tiwari S, Falet H, Hartwig JH, Hoffmeister KM, Andre P, Wagner DD, Shivdasani RA. Mechanisms and implications of platelet discoid shape. Blood. 101:4789-4796, 2003.

Hoffmeister KM, Felbinger TW, Falet H, Denis CV, Bergmeier W, Mayadas TN, von Andrian UH, Wagner DD, Stossel TP, Hartwig JH. The clearance mechanism of chilled blood platelets. Cell. 112:87-97, 2003.

            Faculty of 1000 rating: ****


Massberg S, Brand K, Gruner S, Page S, Muller E, Muller I, Bergmeier W, Richter T, Lorenz M, Konrad I, Nieswandt B, Gawaz M. A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation. J Exp Med. 196:887-896, 2002.

Bergmeier W, Schulte V, Brockhoff G, Bier U, Zirngibl H, Nieswandt B. Flow cytometric detection of activated mouse integrin alphaIIbbeta3 with a novel monoclonal antibody. Cytometry. 48:80-86, 2002.


Schulte V, Snell D, Bergmeier W, Zirngibl H, Watson SP, Nieswandt B. Evidence for two distinct epitopes within collagen for activation of murine platelets. J Biol Chem. 276:364-368, 2001.

Nieswandt B, Brakebusch C*, Bergmeier W*, Schulte V, Bouvard D, Mokhtari-Nejad R, Lindhout T, Heemskerk JW, Zirngibl H, Fassler R. Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen. Embo J. 20:2120-2130, 2001.

Nieswandt B, Bergmeier W, Eckly A, Schulte V, Ohlmann P, Cazenave JP, Zirngibl H, Offermanns S, Gachet C. Evidence for cross-talk between glycoprotein VI and Gi-coupled receptors during collagen-induced platelet aggregation. Blood. 97:3829-3835, 2001.

Nieswandt B, Schulte V, Bergmeier W, Mokhtari-Nejad R, Rackebrandt K, Cazenave JP, Ohlmann P, Gachet C, Zirngibl H. Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice. J Exp Med. 193:459-469, 2001.

Kauffenstein G, Bergmeier W, Eckly A, Ohlmann P, Leon C, Cazenave JP, Nieswandt B, Gachet C. The P2Y(12) receptor induces platelet aggregation through weak activation of the alpha(IIb)beta(3) integrin–a phosphoinositide 3-kinase-dependent mechanism. FEBS Lett. 505:281-290, 2001.

Bergmeier W, Bouvard D, Eble JA, Mokhtari-Nejad R, Schulte V, Zirngibl H, Brakebusch C, Fassler R, Nieswandt B. Rhodocytin (aggretin) activates platelets lacking alpha(2)beta(1) integrin, glycoprotein VI, and the ligand-binding domain of glycoprotein Ibalpha. J Biol Chem. 276:25121-25126, 2001.


Nieswandt B, Bergmeier W, Schulte V, Rackebrandt K, Gessner JE, Zirngibl H. Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain.  J Biol Chem. 275:23998-24002, 2000.

Nieswandt B, Bergmeier W, Rackebrandt K, Gessner JE, Zirngibl H. Identification of critical antigen-specific mechanisms in the development of immune thrombocytopenic purpura in mice. Blood. 96:2520-2527, 2000.

Bergmeier W, Rackebrandt K, Schroder W, Zirngibl H, Nieswandt B. Structural and functional characterization of the mouse von Willebrand factor receptor GPIb-IX with novel monoclonal antibodies. Blood. 95:886-893, 2000.


Viitanen P, Lorimer G, Bergmeier W, Weiss C, Kessel M, Goloubinoff P. Purification of mammalian mitochondrial chaperonin 60 through in vitro reconstitution of active oligomers. Methods Enzymol.98:2013-2217, 1999.